📄 Category

cardiovascular medicine

131 papers

Cardiovascular medicine focuses on the heart and blood vessels, exploring how to prevent, diagnose, and treat conditions that affect our circulation. This vital field ranges from understanding high blood pressure and heart failure to investigating the latest breakthroughs in surgical techniques and lifestyle interventions. Because these discoveries directly impact public health, staying informed about emerging research is more important than ever for both specialists and curious readers.

At Gist.Science, we process every new preprint in this category as it appears on medRxiv, ensuring you have immediate access to the latest findings before they undergo formal peer review. For each study, we provide both a plain-language explanation to clarify the core concepts and a detailed technical summary for those seeking deeper scientific context. Below are the latest papers in cardiovascular medicine, organized to help you navigate the most recent developments shaping the future of heart health.

📄 cardiovascular medicine

Comparative Analysis of Machine Learning Models vs. Traditional Clinical Calculators for Cardiovascular Risk Prediction

This study demonstrates that a calibrated Gradient Boosting machine learning model, developed using NHANES data and integrated into the "CardioPrediQ" platform, achieves superior composite performance and statistical equivalence to top traditional calculators for predicting cardiovascular mortality, offering a scalable solution particularly beneficial for diverse populations where standard risk tools may lack accuracy.

Arango Plaza, N., Salcedo Echeverry, G. E., Arenas-Soto, A. F.2026-06-15
📄 cardiovascular medicine

Healthcare professionals' perspectives on a multilevel cardiovascular risk management intervention (PROSPERA programme)

This study identifies barriers and facilitators among healthcare professionals regarding the implementation of the PROSPERA multilevel cardiovascular risk management programme, highlighting the need for targeted education, training, and environmental restructuring to support its adoption in primary care.

Bongaerts, V. A. M. C., van Gestel, L. C., van Peet, P. G., Vuijk, M.-L. S., Hageman, S. H. J., Dorresteijn, J. A. N., B (…)2026-06-09
📄 cardiovascular medicine

Soft Tissue-to-Bone Ratio on Routine Bone Scintigraphy as an Opportunistic Imaging Biomarker of Cardiovascular-Kidney-Metabolic Burden

This study demonstrates that the soft tissue-to-bone ratio (STBR) derived from routine 99mTc-DPD bone scintigraphy serves as a cost-free, independent prognostic biomarker that effectively captures cumulative cardiovascular-kidney-metabolic burden and predicts increased risks of mortality, major adverse cardiovascular events, and heart failure hospitalization.

Spielvogel, C. P., Kluge, K., Ning, J., Kumpf, K., Nitsche, C., Hengstenberg, C., Slomka, P. J., Hacker, M.2026-06-09✓ Author reviewed ⓘ
📄 cardiovascular medicine

Structural Cardiac Abnormalities, Ventricular Dysfunction Phenotypes, and Heart Failure Risk among Antiretroviral Therapy-treated People Living with HIV in South Africa

In a peri-urban South African community, antiretroviral-treated people living with HIV, particularly women, exhibited a significantly higher prevalence of structural cardiac abnormalities and diastolic dysfunction leading to undiagnosed heart failure with preserved ejection fraction compared to HIV-negative controls.

Omar, Z., PHIZA Study Team,, Ahmed, A. A., Wolfson, J., Huang, Z., Mgidlana, M., Black, A., Abd El Hadi, M., Aremu, O. O (…)2026-06-08
📄 cardiovascular medicine

A Common CD36 Variant and the Genetic Landscape of Dilated Cardiomyopathy in Individuals of African Ancestry

This multicohort study reveals that a common, ancestry-specific CD36 nonsense variant contributes more significantly to the burden of dilated cardiomyopathy in individuals of African ancestry than established genetic causes, including TTN truncating variants, thereby reshaping the understanding of the disease's genetic architecture in this population.

Challa, S., Biddinger, K., Abramowitz, S., Zheng, A., Mead, J. O., Judy, R. L., Jurgens, S., Gaziano, L., Wang, X., Choi (…)2026-05-27
📄 cardiovascular medicine

Wavelet Decomposition-Based Genomic Analysis of the Human Electrocardiogram

This study utilizes wavelet decomposition to analyze UK Biobank ECGs, revealing that high-frequency signals typically filtered as noise contain significant heritable genetic information linked to cardiac conduction, myocardial integrity, and heart failure risk, thereby expanding the known genetic architecture of cardiovascular disease.

Zainana, S., Lauer, L. P., Kiiskinen, T., Tibshirani, R. j., Hastie, T., Ashley, E., O'Sullivan, J. W., Rivas, M. A.2026-05-24
📄 cardiovascular medicine

Should Coronary Revascularization Precede Transcatheter Aortic Valve Replacement? A Meta-Analysis of Randomized Controlled Trials

This meta-analysis of three randomized controlled trials involving 1,156 patients indicates that routine percutaneous coronary intervention (PCI) prior to transcatheter aortic valve replacement (TAVR) does not reduce mortality but significantly lowers the need for revascularization while nearly doubling the risk of bleeding, thereby supporting a selective rather than routine approach to revascularization.

Soliman, D., abdelmalek, J., Puchongmart, C., Sodsri, T., Sivakumar, N., Sly, Z.2026-05-20
📄 cardiovascular medicine

Prevalence and determinants of rheumatic heart disease among school-going children in Dhanusha district, southern Nepal: a cross-sectional echocardiographic screening study

This cross-sectional echocardiographic study of 4,536 school children in Dhanusha, Nepal, reveals the country's highest documented rheumatic heart disease prevalence (18.7 per 1,000), with two-thirds of cases being subclinical and female sex identified as the sole independent predictor, highlighting the critical need for school-targeted screening programs.

Regmi, P. R., Shakya, U., Suwal, S. N., Shah, R. K., Shah, R., Baidhya, P. R., Tamang, A., Thapa, S.2026-05-20
📄 cardiovascular medicine

Association of Circulating Calcitonin With Risk and Onset of Postoperative Atrial Fibrillation After Cardiac Surgery

This study demonstrates that higher preoperative circulating calcitonin levels are independently associated with a reduced risk and delayed onset of postoperative atrial fibrillation in cardiac surgery patients, suggesting its potential utility as a biomarker for perioperative risk stratification.

Yiu, C. H. K., Moreira, L. M., Akoumianakis, I., Rothwell, P., Antoniades, C., Reilly, S.2026-05-19
📄 cardiovascular medicine

Prevalence, Genetics, and Imaging Characteristics of Patients with Mitral Valve Prolapse and Arrhythmogenic Right Ventricular Cardiomyopathy

This study reveals that mitral valve prolapse (MVP) is prevalent in 14% of arrhythmogenic right ventricular cardiomyopathy (ARVC) patients, is strongly associated with *PKP2* mutations, and presents with distinct features such as increased left ventricular mass and wall motion abnormalities rather than the typical arrhythmic MVP characteristics like annular disjunction.

Rich, A. H., Tastet, L., Cristin, L., Jhawar, R., Tang, J. J., Scheinman, M., Delling, F.2026-05-19