📄 Category

cardiovascular medicine

158 papers

CARotid plaqUe StabilizatiOn and regression with evolocumab: the CARUSO Study

The CARUSO study, a randomized trial of patients with significant carotid stenosis, found that while adding evolocumab to standard lipid-lowering therapy did not statistically significantly improve plaque stabilization or regression compared to therapy alone, it was associated with a sevenfold reduction in major adverse vascular events and prevented morphological deterioration, suggesting evolocumab should be considered standard treatment for this population.

Aranzulla, T. C., Gaggiano, A., Quaglino, S. + 7 more2026-03-04📄 cardiovascular medicine

The Threshold for a Clinically Meaningful Improvement in Cardiopulmonary Exercise Testing Measures for Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy

By pooling data from two phase 3 clinical trials, this study establishes that a change in peak oxygen uptake of +0.35 mL/kg/min represents the minimally important difference for patient-perceived clinical improvement in obstructive hypertrophic cardiomyopathy, providing a validated, patient-centered threshold to guide treatment decisions and future trial designs.

Masri, A., Lewis, G. D., Barriales-Villa, R. + 19 more2026-03-04📄 cardiovascular medicine

Get With The Guidelines-Heart Failure Hospital Participation and its Association with Guideline-Directed Medical Therapy and Outcomes

This retrospective analysis of over 1.2 million Medicare beneficiaries demonstrates that hospital participation in the Get With The Guidelines-Heart Failure program is associated with increased adherence to guideline-directed medical therapy and significantly reduced all-cause mortality, though it did not significantly impact heart failure readmission rates.

Verma, A., Fonarow, G. C., Heidenreich, P. + 7 more2026-03-04📄 cardiovascular medicine

Physics-Based Growth and Remodeling Modeling for Virtual Abdominal Aortic Aneurysm Evolution and Growth Prediction

This study proposes a hybrid framework that integrates physics-based growth and remodeling simulations to generate a large virtual cohort of abdominal aortic aneurysms, which, when combined with limited clinical data, significantly enhances the accuracy of machine learning models in predicting aneurysm growth and maximum diameter.

Jahani, F., Jiang, Z., Nabaei, M. + 1 more2026-03-03📄 cardiovascular medicine

Antithrombotic Therapy in Atrial Fibrillation Patients with Prior Complex Percutaneous Coronary Intervention: A Secondary Analysis of the Randomized ADAPT AF-DES Trial

In a secondary analysis of the ADAPT AF-DES trial, NOAC monotherapy was found to be as effective as combination therapy for preventing ischemic events while significantly reducing bleeding risks in atrial fibrillation patients more than one year after both complex and non-complex percutaneous coronary interventions.

Jeon, H.-K., Jeon, H. S., Lee, K. + 20 more2026-03-03📄 cardiovascular medicine

NT-proBNP Thresholds for Early Heart Failure Detection in Asian Patients With Type 2 Diabetes

This large retrospective cohort study of Asian patients with type 2 diabetes establishes that NT-proBNP thresholds for predicting heart failure hospitalization are significantly lower and highly dependent on clinical setting, age, BMI, and renal function, underscoring the need for ethnicity-specific diagnostic criteria rather than relying on Western guidelines.

Lai, T.-S., Tseng, C.-L., Wu, C.-K. + 3 more2026-03-03📄 cardiovascular medicine

Comparison of temporal changes in left atrial and left ventricular strain after septal myectomy, alcohol septal ablation, and cardiac myosin inhibitor

This study demonstrates that while septal myectomy, alcohol septal ablation, and cardiac myosin inhibitors all effectively reduce LVOT gradients in obstructive hypertrophic cardiomyopathy, they exhibit distinct temporal patterns of myocardial functional adaptation, with surgical and ablative therapies showing progressive strain improvement whereas cardiac myosin inhibitors result in stable LV strain but late attenuation of left atrial strain.

Hwang, I.-C., Bak, M., Park, J. + 13 more2026-03-03📄 cardiovascular medicine

Conversational artificial intelligence HeAlth supporT in Atrial Fibrillation Self-Management (CHAT-AF-S): rationale and randomised controlled trial design

This paper outlines the rationale and design of the CHAT-AF-S randomized controlled trial, which aims to evaluate the effectiveness of a conversational artificial intelligence intervention in improving quality of life for adults with atrial fibrillation compared to usual care.

Laranjo, L., Zeng, A., OHagan, E. + 12 more2026-03-03📄 cardiovascular medicine

Design and Rationale of the My Heart Counts Cardiovascular Health Study: a Large-Scale, Fully Digital Biobank, and Randomized Trial of Large Language Model-Driven Coaching of Physical Activity

The My Heart Counts study is a large-scale, fully digital biobank and randomized trial utilizing a cross-platform smartphone application to evaluate the efficacy of large language model-driven, personalized coaching on physical activity compared to generic prompts, while simultaneously building a comprehensive dataset of multimodal health metrics for cardiovascular research.

Schmiedmayer, P., Johnson, A., Schuetz, N. + 15 more2026-03-03📄 cardiovascular medicine

Extracardiac Thoracoabdominal Atherosclerosis in Heart Transplant Candidates is not Associated with Standard Modifiable Cardiovascular Risk Factors

This study demonstrates that among heart transplant candidates, the burden of extracardiac thoracoabdominal atherosclerotic plaque is higher in those with ischemic cardiomyopathy but is not associated with the presence of standard modifiable cardiovascular risk factors, suggesting that these risk factors are ineffective markers for determining the need for atherosclerosis screening in this population.

Readford, T. R., Ugander, M., Kench, P. L. + 4 more2026-03-02📄 cardiovascular medicine

Routine Errors Matter: The Effect of Non-Standardized Blood Pressure Measurement

This quasi-experimental study demonstrates that common non-standardized blood pressure measurement practices, such as unsupported body position, speaking, or crossing legs, lead to significant overestimation of blood pressure values and potential misclassification of hypertension status, thereby risking inappropriate therapeutic decisions.

Vesga-Reyes, P. A., Zapata-Vasquez, I. L., Carrillo-Gomez, D. C. + 3 more2026-03-02📄 cardiovascular medicine

Automated Echocardiographic Detection of Mitral Valve Prolapse and Mitral Regurgitation with Video-based Artificial Intelligence Algorithms

This study demonstrates that fully automated, multi-view deep neural networks can accurately detect mitral valve prolapse and clinically significant mitral regurgitation from echocardiographic videos, achieving high performance in both internal and external validation cohorts.

Ansari, M. U., Barrios, J. P., Tastet, L. + 11 more2026-03-02📄 cardiovascular medicine

THE ASSOCIATION OF NUTRITIONAL STATUS ON FUNCTIONAL CAPACITY AND QUALITY OF LIFE IN CARDIAC AMYLOIDOSIS PATIENTS: AN EXPLORATORY PILOT STUDY

This exploratory pilot study reveals that malnutrition is highly prevalent in cardiac amyloidosis patients, particularly those with the AL subtype, and underscores the limitations of BMI in detecting nutritional deficits while highlighting the critical need for routine screening to improve quality of life and outcomes.

Ribeiro, P. A. B., Grigoletti, S. S., Zuchinali, P. + 4 more2026-03-02📄 cardiovascular medicine

Systematic computational fluid dynamic analysis of intra-aneurysmal blood flow using data-driven synthetic cerebral aneurysm geometries

This study demonstrates that a data-driven approach using principal component analysis to generate synthetic cerebral aneurysm geometries effectively reveals how specific morphological variations, particularly aneurysm height and dome width, systematically govern intra-aneurysmal hemodynamics and wall shear stress patterns.

Yamamoto, Y., Ueda, K., Wakimura, H. + 4 more2026-03-02📄 cardiovascular medicine

A process evaluation of a cluster randomised trial hosted in hairdressing salons promoting women's cardiovascular prevention

This process evaluation of the "Hairdressers for Health" cluster randomised trial found that while using hairdressing salons to promote cardiovascular health checks for women was acceptable and leveraged trusted hairdresser-client relationships, the study faced significant challenges in salon recruitment and participant adoption due to technological constraints and privacy concerns.

Barraclough, J. Y., Ouyang, M., Reading, M. + 7 more2026-03-02📄 cardiovascular medicine

Exercise Reverses the Sedentary Cardiac Phenotype in Obesity: A Systematic Review and Meta-Analysis of Hemodynamic, Structural, and Functional Adaptations

This systematic review and meta-analysis demonstrates that exercise training effectively reverses the sedentary cardiac phenotype in obese individuals by improving hemodynamics and inducing beneficial structural remodeling, with HIIT proving superior for diastolic and mass adaptations and aerobic exercise for blood pressure control, all largely independent of weight loss.

KURTOÄzLU, A., Türkmen, M., Kurtoglu, E. + 1 more2026-02-28📄 cardiovascular medicine